Protein: Q13231 (CHIT1)

This semester, I'm focusing on CHIT1. 

CHIT1 is a gene and encodes a protein called Chitotriosidase-1, and is a member of the chitinase family. This is selectively expressed in activated tissue macrophages.

As a biomarker (it indicates the severity or presence of some disease state) is the best to monitor Gaucher disease from the three most commonly used. Also, it is a marker for macrophage activation in acute ischemic stroke.

Chromosomal location 

Cytogenetic Location: 1q32.1.

1q    = The long (q) arm of the chromosome 1

32.1 =  It is the position in the arm.

Molecular Location: base pairs 203,216,079 to 203,229,673 

Cytogenetic Location: 1q32.1, which is the long (q) arm of chromosome 1 at position 32.1
Data and Picture Reference: Genetics Home Reference.  August 17th, 2020. CHIT1 gene, Chitinase1. Retrieved from: https://ghr.nlm.nih.gov/gene/CHIT1#resources

Function: 

Chitinases works in both innate and adaptive immunity. They are necessary for the following functions:

  • Degrades chitin, chitotriose and chitobiose.
  • May participate in the defense against nematodes and other pathogens
  • It is expressed to  aid in the remodeling of their biological matrices to accommodate changes in body size and shape. 


Similar Gene & Protein

GENE: CHIA

GENE: CHIT1

Protein: acidic mammalian chitinase (AMC)

Protein: chitotriosidase

It is expressed mainly in the gastrointestinal tract and lung 

It is expressed in activated tissue macrophages.

Both are secreted as 50 kDa proteins

Both are secreted as 50 kDa proteins

It is stable under acidic pHS

It is not stable under acidic pHs and can be processed into a C-terminally truncated 39 kDa form


This is what I learned so far from my gene and protein. I will be going more in-depth the following weeks

Comments

  1. Kathleen CorfmanSeptember 6, 2020 at 5:39 PM

    Ooo you're right, ours are both super similar!
    I'm interested to learn more :)

    ReplyDelete
  2. KaylynnSeptember 10, 2020 at 6:53 PM

    Hello Jaira,

    Excellent job on your presentation of your protein!

    I agreed with Kathleen that it will be interesting to compare your proteins towards the end of the semester.

    Great job!

    Chad

    ReplyDelete

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